Integrated traditional Chinese and Western medicine therapy for Wilson disease
- VernacularTitle:肝豆状核变性的中西医结合治疗
- Author:
Yumei GU
1
;
Yeqing HUANG
1
;
Bei ZHANG
1
;
Aiqun LIU
1
;
Zhongxing PENG
1
;
Mingfan HONG
1
;
Zhihua ZHOU
2
Author Information
- Publication Type:Journal Article
- Keywords: Hepatolenticular Degeneration; Dietary Therapy; Integrated Chinese Traditional and Western Medicine Therapy
- From: Journal of Clinical Hepatology 2026;42(3):529-534
- CountryChina
- Language:Chinese
- Abstract: Wilson disease （WD） is one of the few treatable neurogenetic disorders. Currently， Western medicine remains the main treatment method for WD， while since the 1990s， multiple studies conducted by Professor Yang Renmin and his team have shown that traditional Chinese medicine （TCM） also has a favorable therapeutic effect. Based on the principle of low-copper diet for WD， this article systematically elaborates on the advantages， limitations， and key considerations of current Western medicine therapies （pharmacotherapy， liver transplantation， and splenectomy） and reviews the research findings of TCM in China， especially the wide application of Gandou Decoction in clinical practice. Studies have shown that Gandou Decoction can effectively improve neurological symptoms， protect hepatic and renal function， and avoid the adverse drug reactions associated with metal chelating agents， and therefore， it can be used an effective long-term adjuvant therapy for WD. It should be noted that symptoms and signs should be considered in integrated traditional Chinese and Western medicine therapy for WD， and high-copper TCM drugs should be avoided to prevent deterioration.
