Traditional Chinese medicine syndrome and syndrome differentiation-based treatment of Wilson disease
- VernacularTitle:肝豆状核变性的中医证候学与辨证治疗
- Author:
Wenjie HAO
1
;
Wenming YANG
1
;
Ting CHENG
1
;
Hailin JIANG
1
;
Han WANG
1
;
Meixia WANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatolenticular Degeneration; Symptom Complex; Treatment Based on Syndrome Differentiation; Therapeutics （TCM）
- From: Journal of Clinical Hepatology 2026;42(3):522-528
- CountryChina
- Language:Chinese
- Abstract: Wilson disease （WD） is an autosomal recessive disorder of copper metabolism， and decoppering therapy and symptomatic treatment are the main Western medicine therapies for WD. This article systematically reviews the understanding of the etiology and pathogenesis of WD in traditional Chinese medicine （TCM） and points out that abnormal natural endowment is the core etiology and pathogenesis of WD， with internal accumulation of copper toxicity as the manifestation， liver/spleen/kidney dysfunction as the root cause， and intermingled “toxin， stasis， phlegm， and deficiency” as the key pathogenesis. Literature research and clinical observation are conducted to summarize the common TCM syndromes of WD， including stagnation of liver Qi， internal retention of damp-heat， phlegm-stasis-heat accumulation syndrome， liver-kidney Yin deficiency syndrome， spleen-kidney Yang deficiency， and syndrome of deficiency damage and phlegm stasis. This article proposes the corresponding therapies and representative prescriptions for each syndrome and discusses the advantages of treatment by stage and integrated traditional Chinese and Western medicine therapy. This article aims to provide a systematic reference for the syndrome differentiation-based treatment of WD in clinical practice of TCM， thereby giving full play to the advantages of TCM in the treatment of this disease.
