Clinical phenotypes and pathogenic mechanisms of Wilson disease with lipid metabolism disorders
- VernacularTitle:肝豆状核变性患者脂代谢紊乱的临床表型与致病机制
- Author:
Dongjing GAO
1
;
Ruixin WANG
1
;
Xinhua LI
1
Author Information
- Publication Type:Journal Article
- Keywords: Hepatolenticular Degeneration; Lipid Metabolism Disorders; Pathologic Processes
- From: Journal of Clinical Hepatology 2026;42(3):515-521
- CountryChina
- Language:Chinese
- Abstract: Wilson disease （WD） is a hereditary disorder of copper metabolism characterized by abnormal copper accumulation in tissues， including the liver and brain， which leads to severe hepatic and neurological damage. This disease is often accompanied by lipid metabolism abnormalities， and the exploration of related mechanisms has attracted increasing attention. This article introduces the clinical features of lipid metabolism disorders in WD patients， summarizes the research advances in the serum levels of lipids and hepatic steatosis， analyzes the potential mechanisms of the interaction between copper and lipid metabolism， and highlights the significance of lipid-related molecules in disease diagnosis and clinical evaluation. In clinical practice， the monitoring and assessment of lipid metabolism parameters should be taken seriously in patients with WD， in order to promote comprehensive disease management and improve the prognosis of patients.
