Aggression is a major challenge in psychiatric settings, particularly among service users with schizophrenia. Psychiatric nurses are at the frontline of aggression prevention thus making their strategies vital for safe, high-quality care.

This study examined the strategies used by psychiatric nurses in preventing aggression among adult schizophrenia service users at the National Center for Mental Health (NCMH) and also analyzed the relationship between nurses' demographic profiles and their prevention strategies.

A quantitative, descriptive-correlational, comparative design was employed. A total of 18 head nurses and 87 staff nurses were selected through purposive sampling. Data was collected using a researcher-developed questionnaire and analyzed using descriptive statistics and correlation tests to determine associations between nurse profiles and aggression prevention strategies. Ethical approval was also obtained prior to data collection.

Most head nurses were female (77.78%), aged 30–39 years (44.44%), and held a BSN degree (77.78%). Staff nurses were also predominantly female (57.47%), aged 30–39 (67.82%), and BSN graduates (96.55%). Both groups frequently applied risk assessment, de-escalation, therapeutic communication, and medication administration. Significant relationships were found between age, sex, education, and length of service, and nurses' ability to prevent aggression. No significant differences were found between head nurses and staff nurses in their self-assessed ability to prevent aggression.

Psychiatric nurses' age, education, and experience significantly influence aggression prevention strategies. Strengthening training in risk assessment, de-escalation, therapeutic communication, and medication administration is essential for enhancing nurse competency and ensuring safer mental health care.