Medication safety is a global priority, yet in the Philippines, particularly in rural hospitals, it remains underexplored. Nurses are at the frontline of safeguarding patients, often working under resource constraints.

This study explored nurses' perspectives on medication safety in rural Philippine hospitals, while focusing on systemic barriers, emotional and ethical challenges, and strategies employed to sustain safe practice.

Aqualitative design was used that employed focus group discussions (FGDs) and key informant interviews (KIIs) with staff nurses in rural hospitals. Thematic analysis was conducted to identify themes and subthemes emerging from participants' experiences.

Three themes emerged: (1) Building Responsibility and Skills (accountability, verification, documentation, and mentorship); (2) Keeping Patients Safe and Reducing Mistakes (protecting patient care, overcoming systemic barriers); and (3) Handling Emotions and Challenges in Giving Medicine (coping with guilt, moral distress, and reliance on teamwork). Findings revealed that nurses sustain safety through vigilance and accountability but are constrained by chronic understaffing, interruptions, moral distress, and limited training access.

Medication safety in rural Philippine hospitals is shaped by nurses' competence, emotional resilience, and teamwork, but remained fragile without systemic supports. Implications included equitable workforce policies, supportive errorreporting cultures, and strengthened continuing professional development opportunities. Strengthening safety also required shifting from individual responsibility to organizational and system-level accountability.