Research progress in natural N-glycosides and synthetic methodologies for the formation of N-glycosidic bonds
10.1097/st9.0000000000000035
- Author:
Yingting XIA
1
;
Qingxia XU
2
;
Alastair N. HERRON
3
;
Wenjun WANG
1
;
Lidong SHAO
4
;
Guodong LI
4
;
An LIU
2
;
Jintang CHENG
2
Author Information
1. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China; School of Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China
2. State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing, China
3. Gilead Sciences, Inc, Foster City, CA, USA
4. School of Chinese Medicine, Yunnan University of Traditional Chinese Medicine, Kunming, China
- Publication Type:Journal Article
- Keywords:
N-glycosides;
Natural products;
Bioactivities;
Synthetic methodology;
Regioselectivity
- From:
Science of Traditional Chinese Medicine
2024;2(2):82-94
- CountryChina
- Language:English
-
Abstract:
N-glycosides comprise a broad range of compounds, some of which have demonstrated a variety of bioactivities, such as antiviral, antitumor, and antibacterial activities. Serving as essential building blocks for DNA and RNA, nucleosides are a particularly important subclass of N-glycosides. Accordingly, natural N-glycosides and their analogs have garnered great interests of both organic and pharmaceutical chemists, who have developed numerous synthetic methods for the preparation of N-glycosides. By reviewing the natural N-glycosides published between 1980 and 2023, this article summarizes current strategies for synthesizing N-glycosides, aiming to provide support for the development and research of N-glycosides.
