Bacteriostatic activity and mechanism of minerals containing rubidium
10.1097/st9.0000000000000064
- Author:
Yucui LU
1
;
Xianmei LONG
2
;
Yuanhui MAO
2
;
Lijing WANG
3
;
Xiayun LIAO
4
;
Lichun ZHAO
5
Author Information
1. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China; College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China
2. Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, China
3. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China
4. College of Pharmacy, Guangxi University of Chinese Medicine, Nanning, China; Guangxi Key Laboratory of Homologous Resources Development of Medicine and Food, Nanning, China
5. College of Pharmaceutical Sciences, Guizhou University of Traditional Chinese Medicine, Guiyang, China; Institute of Traditional Chinese and Zhuang-Yao Ethnic Medicine, Guangxi University of Chinese Medicine, Nanning, China; Guangxi Key Laboratory of Homologous Resources Development of Medicine and Food, Nanning, China
- Publication Type:Journal Article
- Keywords:
Rubidium ion;
Minerals containing rubidium;
Bacteria;
Antibacterial activity
- From:
Science of Traditional Chinese Medicine
2025;3(2):137-144
- CountryChina
- Language:English
-
Abstract:
Background: Metals and their ions have been used to reduce bacterial infection risks. Among them, minerals containing rubidium (MCR), natural minerals containing metal ions, show potential as novel and tunable materials. Objective: This study aimed to investigate the antibacterial activity and mechanism of MCR. Methods: The inhibitory effect of MCR on bacteria was clarified using the growth curve method, turbidimetric method, and minimum inhibitory concentration method. Physiological and biochemical indices were employed to investigate the inhibitory mechanism of MCR. Results: The results revealed that MCR inhibited Staphylococcus aureus, Listeria monocytogenes, and Escherichia coli with minimum inhibitory concentrations of 11.95, 2.60, and 2.60 mg/mL, respectively. The inhibitory activity of MCR was insignificant against Bacillus subtilis, Salmonella typhimurium, and Helicobacter pylori at 3.25 mg/mL. Mechanistic assessments showed that MCR affected bacterial conductivity, protein and nucleic acid levels, reducing sugar content, respiratory chain dehydrogenase activity, bacterial lipid peroxidation, intracellular adenosine triphosphate, and extracellular alkaline phosphatase. Conclusion: MCR has bacteriostatic activity and the mechanism primarily involves adhesion to bacteria, disrupting the integrity of their cell walls and membranes, and altering their permeability. This disruption leads to the release of intracellular molecules of various sizes, inhibiting cellular respiration and metabolism, and causing oxidative damage. These combined effects impair cellular functions, affecting cell growth and metabolism, or leading to cell death. These findings provide a theoretical reference for the development of MCR as a bacteriostatic agent.
