Research progress in the role of c-Fos protein of in eye diseases
10.19405/j.cnki.issn1000–1492.2026.02.024
- VernacularTitle:c-Fos蛋白在眼科疾病中的作用研究进展
- Author:
Mengqiu SHANG
1
;
Lina LIANG
1
Author Information
1. Department of Eye Function Laboratory， Eye Hospital， China Academy of Chinese Medical Sciences， Beijing 100040
- Publication Type:Journal Article
- Keywords:
c-Fos protein;
eye diseases;
glaucoma;
amblyopia;
retinitis pigmentosa;
diabetic retinopathy
- From:
Acta Universitatis Medicinalis Anhui
2026;61(2):362-368
- CountryChina
- Language:Chinese
-
Abstract:
As a functional anatomical marker of cellular activity and neural circuitry， c-Fos protein has been extensively utilized in studies which investigate neuroendocrine regulation， autonomic nervous system activity， and behavioral responses to stress. Recent research in ophthalmology has revealed that dynamic c-Fos expression is closely associated with pathophysiological processes such as retinal ganglion cell apoptosis， visual cortical plasticity， photodamage repair， and angiogenesis. This review aims to summarize the mechanistic roles of c-Fos protein in ocular diseases including glaucoma， amblyopia， and retinopathy， as well as exploring potential therapeutic approaches targeting c-Fos modulation. The studies have shown that the activation of c-Fos protein can promote the development of neurons in the visual cortex， and the inhibition of c-Fos can delay the apoptosis of retinal ganglion cells， neuroglia and photoreceptors in retinal and optic nerve diseases.
