Effects of polysaccharide liposomes of dendrobium officinale targeting hair follicles in the treatment of androgenetic alopecia
10.11665/j.issn.1000-5048.2025091401
- VernacularTitle:靶向毛囊的3种相对分子质量铁皮石斛多糖脂质体治疗雄激素性脱发的效应研究
- Author:
Li XIA
1
;
Sijie ZHAO
;
Yang HU
;
Yafei WAN
Author Information
1. 南京中医药大学连云港附属医院, 连云港222004;中国药科大学药学院, 南京210009
- Publication Type:Journal Article 期刊文章
- Keywords:
dendrobium officinale polysaccharides;
androgenic alopecia;
liposomes;
hair follicle targeting;
human dermal papilla cells
- From:
Journal of China Pharmaceutical University
2026;57(2):224-232
- CountryChina
- Language:Chinese
-
Abstract:
Based on previous research on the promoting effect of dendrobium officinale polysaccharides (DOP) on hair growth, this study aimed to regulate the skin keratin penetration and hair follicle targeting ability of DOP through molecular weight and nano-carriers to enhance its therapeutic effect on androgenetic alopecia (AGA). Three molecular weight polysaccharides, namely high (DOP), medium (MDOP), and low (LDOP), were prepared by mannanase hydrolysis, and the corresponding liposomes (DOP-lip/MDOP-lip/LDOP-lip) were constructed. Studies have shown that DOP liposomes can effectively achieve follicular targeted delivery and promote efficient uptake by human dermal papilla cells through caveolin-mediated pathways. In the testosterone-induced AGA mouse model, LDOP-lip demonstrated excellent therapeutic effects, restoring the number and morphology of hair follicles to nearly normal levels. In summary, DOP liposomes show significant potential for promoting hair follicle repair through precise delivery and efficient cellular uptake.
