Advances in evaluation techniques for traditional Chinese medicine dermatopharmacokinetics
10.11665/j.issn.1000-5048.2025090901shu
- VernacularTitle:中药皮肤药代动力学评价技术研究进展
- Author:
Yiqiao CHEN
1
;
Lu SUN
;
Xiaodong WEN
Author Information
1. 中国药科大学附属江宁中医院（南京市江宁中医院）, 南京 211100;中国药科大学中药学院生药学系, 南京211198
- Publication Type:Journal Article 期刊文章
- Keywords:
traditional Chinese medicine dermatopharmacokinetics;
tape stripping;
microdialysis/open flow microperfusion;
confocal Raman microscopy;
matrix-assisted laser desorption/ionization mass spectrometry imaging
- From:
Journal of China Pharmaceutical University
2026;57(2):172-180
- CountryChina
- Language:Chinese
-
Abstract:
Evaluating the absorption of traditional Chinese medicine (TCM) formulations in skin has long been a challenge in cutaneous pharmacokinetic studies of TCM. In recent years, various new techniques, including diffusion cell, microphysiological system, matrix-assisted laser desorption/ionization mass spectrometry imaging, tape stripping, microdialysis/open-flow microperfusion, and confocal Raman microscopy technology, have been developed to characterize and predict the pharmacokinetic profiles of these formulations more accurately. This review systematically summarizes the application progress of these methods in the evaluation of cutaneous pharmacokinetics of TCM, highlights their technical features and suitable scenarios, and discusses future development trends, providing new research perspectives for further understanding the dynamic changes, spatial distribution characteristics of active ingredients in the skin, and the rationality of compatibility in topical preparations.
