Cytochrome P450 enzymes from Streptomyces: functions and engineering approaches for applications
10.11665/j.issn.1000-5048.2025122502
- VernacularTitle:链霉菌细胞色素P450酶的功能及改造和应用
- Author:
Yingying YIN
1
;
Yijun CHEN
Author Information
1. 中国药科大学生命科学与技术学院, 南京 211198
- Publication Type:Journal Article 期刊文章
- Keywords:
cytochrome P450 enzymes;
Streptomyces;
natural products;
biosynthesis;
industrial application
- From:
Journal of China Pharmaceutical University
2026;57(2):144-154
- CountryChina
- Language:Chinese
-
Abstract:
Cytochrome P450 enzymes represent a class of heme-containing protease widely distributed across the biological kingdom. Endowed with a broad substrate scope, diverse catalytic reaction profiles, high regio- and stereoselectivity toward substrates, and mild catalytic conditions, these enzymes stand out as superior biocatalysts with good potential of application. As one of the primary producers of natural products, Streptomyces harbors a wealth of P450 enzymes and natural product biosynthetic gene clusters (BGCs) in its genome, making it a versatile treasure trove for the generation of bioactive small-molecule compounds. This review summarizes the catalytic reactions by Streptomyces-derived P450 enzymes in natural product biosynthesis and delineates the engineering strategies for addressing the practical application challenges of P450 enzymes, aiming to provide some reference and guidance for in-depth research on P450 enzymes and their applications.
