Effects and molecular mechanisms of Abelmoschi Corolla and its active flavonoids in the treatment of diabetic nephropathy
10.11665/j.issn.1000-5048.2025031701
- VernacularTitle:黄蜀葵花及其黄酮类活性成分治疗糖尿病肾病的作用及机制
- Author:
Yihong YU
1
;
Nan LI
;
Jie WU
Author Information
1. 中国药科大学生命科学与技术学院, 南京211100;南京中医药大学附属江苏省中医院内分泌科, 南京210029
- Publication Type:Journal Article 期刊文章
- Keywords:
Abelmoschi Corolla;
diabetic nephropathy;
flavonoid;
mechanism
- From:
Journal of China Pharmaceutical University
2026;57(1):115-121
- CountryChina
- Language:Chinese
-
Abstract:
Abelmoschi Corolla is extensively applied in managing diabetic nephropathy (DN) and other renal conditions due to its diuretic and detoxifying properties. The primary bioactive constituents of Abelmoschi Corolla are flavonoids, including notably rutin, hyperoside, isoquercitrin, hibifolin, myricetin, quercetin 3-O-β-D-glucuronide, and quercetin. These flavonoid components can influence the pathological progression of DN via a multi-target synergistic mechanism, effectively reducing proteinuria levels. This review examines the roles of Abelmoschi Corolla and its flavonoid components in modulating the key pathological aspects of DN and their underlying mechanisms, and briefly discusses the metabolic patterns of its bioactive components and the research progress in combined medication, aiming to provide a forward-looking scientific foundation for further investigating the molecular mechanisms and clinical applications of Abelmoschi Corolla in DN treatment.
