Research progress of Plasmodium falciparum histone deacetylase inhibitors
10.11665/j.issn.1000-5048.2025031901
- VernacularTitle:疟原虫组蛋白去乙酰化酶抑制剂研究进展
- Author:
Lei ZHAO
1
;
Mengdie ZHANG
;
Peng SUN
Author Information
1. 国家药品监督管理局药品评审中心, 北京102600;中国中医科学院青蒿素研究中心, 北京100700
- Publication Type:Journal Article 期刊文章
- Keywords:
malaria;
Plasmodium falciparum;
histone deacetylase;
inhibitor
- From:
Journal of China Pharmaceutical University
2026;57(1):28-33
- CountryChina
- Language:Chinese
-
Abstract:
Histone deacetylase has proved to be a promising new antimalarial target in the development of novel antimalarial drugs. This article introduces the mechanism of action of histone deacetylase inhibitors and their antimalarial activity, with a focus on the discovery process of Plasmodium histone deacetylase inhibitors and their recent research progress both domestically and internationally. Recent research findings on hydroxamic acid-based and cyclic peptide inhibitors are reviewed and analyzed in detail according to their different structural types. Key challenges hindering drug development and approval, such as drug toxicity issues and the lag in related biological studies, are highlighted. Furthermore, future directions for drug research and development are proposed, offering insights for the further development of new antimalarial drugs.
