Research advances in STING agonist-based antibody-drug conjugates
10.11665/j.issn.1000-5048.2025031201
- VernacularTitle:基于STING激动剂抗体偶联药物的研究进展
- Author:
Jing ZHANG
1
;
Depeng LI
;
Bin YU
;
Zhiyu LI
;
Jinlei BIAN
Author Information
1. 中国药科大学药学院, 南京 210009
- Publication Type:Journal Article 期刊文章
- Keywords:
immune-stimulating antibody drug conjugate;
stimulator of interferon genes agonist;
antibody drug conjugate;
immune response
- From:
Journal of China Pharmaceutical University
2026;57(1):19-27
- CountryChina
- Language:Chinese
-
Abstract:
Immune-stimulating antibody drug conjugate (ISAC) can not only effectively solve the defects of stimulator of interferon genes (STING) agonists by coupling antibodies with STING agonists through the targeting of antibodies, but also play a synergistic role with antibodies to further improve the efficacy of STING agonists. This review first provides a concise overview of the current research landscape of ISACs and STING agonists, systematically elaborates on evolving trends in STING agonist development, and subsequently summarizes the mechanistic advances in STING ISAC research. Special emphasis is placed on representative STING ISAC candidates in preclinical/clinical development. Finally, the future directions of STING ISACs are critically discussed with perspectives and recommendations, aiming to provide theoretical insights and practical guidance for future investigations.
