New trends and new strategies of drug repurposing: 2020–2024
10.11665/j.issn.1000-5048.2025072102
- VernacularTitle:2020−2024年：解锁 “老药新用” 新趋势与新策略
- Author:
Fangsu CHEN
1
;
Junjie YANG
;
Jiayu DU
;
Shimiao HUANG
;
Yuxuan ZHANG
;
Qidong YOU
;
Lei WANG
;
Qiuyue ZHANG
Author Information
1. 中国药科大学江苏省创新药物设计与成药性优化重点实验室, 南京210009;中国药科大学药学院, 南京210009
- Publication Type:Journal Article 期刊文章
- Keywords:
drug repurposing;
drug development strategies;
new indications;
research progress
- From:
Journal of China Pharmaceutical University
2026;57(1):11-18
- CountryChina
- Language:Chinese
-
Abstract:
The research and development of innovative drug have progressed remarkably, but the long development circle and high failure rate have become the bottleneck. Drug repurposing, discovering new indications of approved drugs, is a strategy to overcome these obstacles. By exploring new indications for approved drugs, rapid progress has been made in basic research and clinical translation in recent years. Rich resources of drugs, proven security, efficient development workflow and reduced cost are core advantages of this strategy, making the strategy a crucial direction of optimizing the pipeline of drug research and development. This review systematically summarizes drug repurposing cases that have received clinical approval over the past five years, and proposes core strategies for drug repurposing, including approaches based on targets, pathways, drug similarity, post-treatment phenotypes, and clinical side effects, aiming to provide some strategic guidance for drug repurposing efforts.
