VEGF Inhibitor–Associated Side Effects in Antitumor Therapy and Intervention Strategies
10.3971/j.issn.1000-8578.2026.25.0759
- VernacularTitle:VEGF抑制剂的抗肿瘤相关常见不良反应及其干预策略
- Author:
Lu LIU
1
;
Wanting SUN
2
;
Shuning YAO
1
;
Zhenyu CHEN
1
;
Yuefei WANG
3
;
Jing YANG
3
Author Information
1. Institute of Traditional Chinese Medicine, National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
2. College of Chinese Materia Medica, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China.
3. Institute of Traditional Chinese Medicine, National Key Laboratory of Chinese Medicine Modernization, Tianjin University of Traditional Chinese Medicine, Tianjin 301617, China;Haihe Laboratory of Modern Chinese Medicine, Tianjin 301617, China.
- Publication Type:REVIEWS
- Keywords:
VEGF inhibitor;
Antitumor;
Hypertension;
Proteinuria;
Hand-foot skin reaction;
Myelosuppression;
Intervention strategy
- From:
Cancer Research on Prevention and Treatment
2026;53(4):289-300
- CountryChina
- Language:Chinese
-
Abstract:
Vascular endothelial growth factor (VEGF) inhibitors are drugs that target and inhibit tumor angiogenesis. By blocking the signaling pathway of VEGF and its receptor, they suppress tumor proliferation and play a crucial role in tumor treatment. However, their side effects, such as hypertension, proteinuria, hand-foot skin reactions, and myelosuppression, during treatment seriously affect patients' treatment compliance and quality of life. The development of intervention strategies for the side effects of VEGF inhibitors is of great importance for tumor treatment. This article reviews the clinical characteristics and toxic mechanisms of common side effects caused by VEGF inhibitors during tumor treatment and summarizes intervention strategies that combine traditional Chinese and Western medicines. Drug dosages were precisely monitored and adjusted to achieve antitumor treatment. Patients' discomfort symptoms are improved through prescriptions that act by tonifying qi and promoting blood circulation, strengthening the spleen, and tonifying the kidney. The combination of traditional Chinese and Western medicines is used to treat patients, thus providing a safe and effective treatment plan for patients with cancer.
