Research Progress on Regulation of Relevant Pathways by Traditional Chinese Medicine for Prevention and Treatment of Parkinson's Disease
10.13422/j.cnki.syfjx.20251905
- VernacularTitle:中医药调控相关信号通路防治帕金森病的研究进展
- Author:
Zhonghao GUO
1
;
Quan LI
1
;
Pengyu PAN
1
;
Tengyu ZHAO
1
;
Zeyuan AN
1
;
Yuan LIU
1
;
Yanyan ZHOU
1
Author Information
1. School of Basic Medical Sciences， Heilongjiang University of Chinese Medicine， Harbin 150040，China
- Publication Type:Journal Article
- Keywords:
Parkinson's disease;
traditional Chinese medicine;
signal pathways;
mechanism of action;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):333-342
- CountryChina
- Language:Chinese
-
Abstract:
Parkinson's disease （PD） is a common neurodegenerative disorder characterized by motor impairments， with its pathological mechanisms involving multiple processes such as the degeneration of dopaminergic neurons and the abnormal aggregation of α-synuclein. Current Western medical treatments face challenges including diminished long-term efficacy and motor complications. In recent years， Traditional Chinese Medicine （TCM） has demonstrated advantages in the prevention and treatment of PD through its systematic regulatory capabilities， featuring multi-component， multi-target， and multi-pathway approaches.This article systematically reviews the roles of seven key signaling pathways-NF-κB， AMPK/mTOR， PI3K/Akt， MAPKs， Nrf2/ARE， Wnt/β-catenin， and BDNF/TrkB-in the pathological process of PD and the regulatory mechanisms of TCM. Research indicates that active ingredients of Chinese herbs and compound formulations can synergistically modulate these pathways， exerting comprehensive effects in inhibiting neuroinflammation， alleviating oxidative stress， promoting autophagy to clear abnormal proteins， and enhancing neurotrophic support. These signaling pathways form a complex regulatory network through crosstalk among key nodal molecules， constituting an intricate regulatory system in PD pathology. The multi-target intervention characteristics of TCM align well with this network-based regulatory requirement， achieving integrated anti-inflammatory， antioxidant， autophagy-regulating， and neurorestorative effects through synergistic multi-pathway modulation. This article systematically outlines the mechanisms of TCM in the coordinated regulation of multiple pathways， providing a theoretical basis for elucidating the pathological process of PD and the intervention mechanisms of TCM， while also offering new perspectives and directions for modern research on TCM in the prevention and treatment of PD.
