Regulatory Mechanisms of miRNA in Hepatocellular Carcinoma and Current Status of Traditional Chinese Medicine Intervention： A Review
10.13422/j.cnki.syfjx.20260168
- VernacularTitle:miRNA在肝细胞癌中的调控机制及中医药干预现状
- Author:
Shiyi LI
1
;
Hao CHENG
1
;
Chunyan JI
1
;
Jun SUN
1
;
Juan XUE
2
Author Information
1. First Clinical College，Hubei University of Chinese Medicine，Wuhan 430065，China
2. Hubei Provincial Hospital of Integrated Traditional Chinese and Western Medicine，Wuhan 430015，China
- Publication Type:Journal Article
- Keywords:
hepatocellular carcinoma;
microRNA;
traditional Chinese medicine;
active constituents;
medicinal pairs;
formulas;
biomarkers
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):323-332
- CountryChina
- Language:Chinese
-
Abstract:
Hepatocellular carcinoma（HCC）， as one of the common malignant tumours， has seen a continuous rise in incidence and mortality worldwide， posing a serious threat to human health. However， traditional treatments have certain limitations， therefore， the exploration of new therapeutic strategies is particularly urgent. In recent years， with in-depth research on the regulatory mechanisms of microRNA（miRNA） in tumour occurrence and development， it has become new targets for HCC diagnosis and treatment. As a traditional treatment method， Chinese medicine， due to its multi-component， multi-pathway， and multi-target overall regulatory characteristics， shows broad prospects in treating HCC by regulating miRNAs. Accordingly， this paper reviews recent studies on the role of miRNAs in HCC and research advances in traditional Chinese medicine interventions， finding that various miRNAs play key roles in HCC cell cycle regulation， proliferation and apoptosis， invasion and metastasis， immune microenvironment， and drug resistance. It summarises how active ingredients， extracts， medicinal pairs， and formulas of Chinese medicine act on specific miRNAs to regulate their downstream target gene expression， affecting the malignant behaviour of HCC cells and exerting anti-cancer effects. This study aims to provide a theoretical basis for miRNAs as potential biomarkers and therapeutic targets for HCC， as well as to offer new ideas for developing miRNA-based targeted Chinese medicine therapies.
