Traditional Chinese Medicine Intervening Mitochondrial Dysfunction for Treatment of Diabetic Kidney Disease： A Review
10.13422/j.cnki.syfjx.20251995
- VernacularTitle:中药干预线粒体功能障碍治疗糖尿病肾病研究进展
- Author:
Xiaochen WEN
1
;
Ying WANG
1
;
Ruoshi LIU
2
;
Ziying LIU
3
;
Xiaoyan MA
4
;
Chengjun GONG
4
Author Information
1. School of Integrated Chinese and Western Medicine，Liaoning University of Traditional Chinese Medicine（TCM），Shenyang 110847，China
2. The First Hospital of China Medical University，Shenyang 110001，China
3. The First Clinical College of Liaoning University of TCM，Shenyang 110847，China
4. The Affiliated Hospital of Liaoning University of TCM，Shenyang 110032，China
- Publication Type:Journal Article
- Keywords:
mitochondrial dysfunction;
diabetic kidney disease;
energy metabolism;
oxidative stress;
traditional Chinese medicine
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):300-311
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic kidney disease （DKD） is a microvascular complication of diabetes， with a complex pathogenesis， in which mitochondrial dysfunction is considered to be the core of DKD development. Taking mitochondria as a target to regulate mitochondrial energy metabolism， mitochondrial oxidative stress， mitophagy， and mitochondrial dynamic function represents a promising strategy for the DKD prevention and treatment， with good prospects in clinical application. Traditional Chinese medicine （TCM） has great potential to mediate mitochondrial dysfunction in the DKD prevention and treatment. This article deeply explores the intrinsic relationship between various forms of mitochondrial dysfunction and DKD， and summarizes the current research status of various Chinese herbal compounds and Chinese herbal formulas in targeting mitochondrial dysfunction for the DKD prevention and treatment. This article aims to provide new targets and strategies for the DKD prevention and treatment， and the research and development of TCM.
