Pathogenesis of Diabetic Nephropathy and Traditional Chinese Medicine Intervention Based on Signaling Pathways： A Review
10.13422/j.cnki.syfjx.20251437
- VernacularTitle:基于信号通路探讨糖尿病肾病的发病机制及中药干预研究进展
- Author:
Yaohong LU
1
;
Chenjie HUANG
1
;
Wenqi YUAN
1
;
Haidong ZHOU
1
;
Gengxin LIU
1
;
Gedi ZHANG
1
;
Ziyou YAN
2
Author Information
1. Clinical Medical College， Jiangxi University of Chinese Medicine， Nanchang 330004， China
2. Affiliated Hospital， Jiangxi University of Chinese Medicine， Nanchang 330006， China
- Publication Type:Journal Article
- Keywords:
traditional Chinese medicine;
pathogenesis;
diabetic nephropathy;
signaling pathway
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):287-299
- CountryChina
- Language:Chinese
-
Abstract:
Diabetic nephropathy （DN） is one of the most common and severe microvascular complications of diabetes， with a complex pathogenesis involving immune inflammatory responses， oxidative stress， apoptosis， glomerulosclerosis， renal interstitial fibrosis， and other pathological processes. In recent years， numerous animal or cell model experiments have revealed that the transforming growth factor-β （TGF-β）/mothers against decapentaplegic homolog （Smad）， phosphoinositide 3-kinase （PI3K）/ protein kinase B （Akt）/mammalian target of rapamycin （mTOR）， mitogen-activated protein kinase （MAPK）， AMP-activated protein kinase （AMPK）， nuclear factor-κB （NF-κB）， Janus kinase （JAK）/signal transducer and activator of transcription （STAT）， neurogenic locus notch homolog protein （Notch）， nuclear factor E2-related factor 2 （Nrf2）， secretory glycoprotein （Wnt）/β-catenin， and other classical signaling pathways play important roles in the occurrence and development of DN. Traditional Chinese medicines， as natural drugs， possess characteristics such as multiple components， multiple targets， and few adverse reactions， demonstrating unique advantages in regulating the aforementioned signaling pathways and improving renal pathological changes. This review summarized recent research progress on the intervention of DN through the regulation of the aforementioned signaling pathways by single compounds and formulas of traditional Chinese medicine， focusing on their mechanisms of action in regulating immune inflammatory responses， inhibiting renal fibrosis， oxidative stress， improving metabolic disorders， and other aspects. The aim is to provide theoretical references for a deeper understanding of the modern pharmacological basis and clinical application of traditional Chinese medicine in the treatment of DN.
