Mechanisms of Traditional Chinese Medicine in Regulating Angiogenesis： A Review
10.13422/j.cnki.syfjx.20260262
- VernacularTitle:中医药调控血管新生作用机制的研究进展
- Author:
Zeming ZHANG
1
;
Lanchun LIU
1
;
Qiyang LI
2
;
Xuan SUN
1
;
Ruoqi ZHANG
1
;
Yiyao ZHANG
1
;
Jie WANG
1
Author Information
1. Guang'anmen Hospital，China Academy of Chinese Medical Sciences，Beijing 100053，China
2. Hubei University of Chinese Medicine，Wuhan 430000，China
- Publication Type:Review
- Keywords:
angiogenesis;
bidirectional regulation;
ischemic diseases;
signaling pathways;
traditional Chinese medicine;
multi-channel collaboration
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):277-286
- CountryChina
- Language:Chinese
-
Abstract:
Angiogenesis， as a core mechanism for maintaining tissue perfusion and repairing ischemic injury， plays a crucial role in ischemic diseases such as coronary heart disease and peripheral arterial disease. Traditional Chinese medicine（TCM）， with its advantages of multi-target and synergistic regulation， provides a unique perspective for therapeutic angiogenesis. Based on this， this article intends to delve into the synergistic effects of key signaling pathways， including vascular endothelial growth factor（VEGF）/VEGF receptor（VEGFR）， Notch， phosphoinositide 3-kinase/ protein kinase B/mammalian target of rapamycin（PI3K/Akt/mTOR）， and angiopoietin/endothelial TEK tyrosine kinase（Ang/Tie2）， and elucidate the driving mechanisms of endothelial cell metabolic reprogramming and exosome-mediated intercellular communication within this process. Based on existing literature， it summarizes the microenvironment-dependent and bidirectional regulatory characteristics of natural active components of TCM（such as terpenes， tanshinones， and flavonoids） on angiogenesis. Furthermore， it systematically discusses how classical TCM formulas achieve blood vessel formation and functional maturation by protecting the neurovascular units， recruiting pericytes， and remodeling the microenvironment. Current evidence highlights the advantages of multi-target synergy and temporal regulation in TCM， but also reveals challenges such as high heterogeneity and a lack of functional evaluations and high-quality clinical trials. Future efforts should integrate multi-omics to decipher network mechanisms， optimize formula compatibility， and conduct multicenter studies to promote the development of innovative preparations. This review highlights the academic value of TCM in angiogenesis， provides an evidence base for treating ischemic diseases， and supports multidisciplinary integration and innovation.
