Development of a Diagnostic Scale for Qi-Yin Deficiency with Blood Stasis Syndrome in Diabetic Macrovascular Disease
10.13422/j.cnki.syfjx.20260294
- VernacularTitle:糖尿病大血管病变气阴两虚夹瘀证诊断量表的编制
- Author:
Qingzhi LIANG
1
;
Ting LUO
1
;
Yi SU
1
;
Xiaoqin LIU
1
;
Hong GAO
1
;
Hongyan XIE
1
;
Chunguang XIE
1
Author Information
1. Traditional Chinese Medicine Regulating Metabolic Diseases Key Laboratory of Sichuan Province，Hospital of Chengdu University of Traditional Chinese Medicine（TCM），Chengdu 610075，China
- Publication Type:Journal Article
- Keywords:
diabetic macrovascular disease;
Qi-Yin deficiency with blood stasis syndrome;
Delphi method;
analytic hierarchy process;
factor analysis;
combined weighting method
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):225-234
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo construct a standardized diagnostic scale for Qi-Yin deficiency with blood stasis syndrome in diabetic macrovascular disease. MethodsLiterature related to Qi-Yin deficiency with blood stasis syndrome in diabetic macrovascular disease was retrieved from CNKI， VIP， and Wanfang databases. Diagnostic information from four diagnostic methods was extracted and standardized， with items having a frequency of ≥15 included in the item pool. A three-round Delphi expert consultation was conducted， screening items using support degree， mean score， rank sum， and coefficient of variation. Item weights were determined using analytic hierarchy process （AHP）， gactor analysis （FA）， and combined weighting method （CWM）. The optimal weighting method was selected by comparing the area under the receiver operating characteristic （ROC） curve （AUC）. The Youden index was calculated to establish the diagnostic cutoff value， which was proportionally scaled. ResultsA total of 102 studies were included. Thirty-five items were incorporated into the item pool. The authority coefficients for the three Delphi rounds were 0.82， 0.85， and 0.86， with coordination coefficients of 0.648， 0.538， and 0.506， respectively. Fifteen items were retained after screening. ROC curve analysis showed the AUC ranking as FA > CWM > AHP. The maximum Youden index was 0.814， corresponding to a diagnostic cutoff of 8.361 （scaled to 40 points）. The final scale adopted a structured diagnostic framework： the symptom dimension requires at least 2 items， and the tongue or pulse dimension requires at least 1 category. ConclusionThis study developed a standardized diagnostic scale for Qi-Yin deficiency with blood stasis syndrome in diabetic macrovascular disease. Core items were screened via the Delphi method， with factor analysis identified as the optimal weighting method through AUC comparison. The diagnostic threshold （40 points） and structured diagnostic framework provide a quantitatively clear， clinically practical tool.
