Clinical Efficacy of Shenqi Yangxin Decoction in Treatment of Patients with Ischemic Cardiomyopathy and Its Effect on Serum H2S and Ca2+
10.13422/j.cnki.syfjx.20260692
- VernacularTitle:参芪养心汤治疗缺血性心肌病患者的临床疗效及对血清H2S、Ca2+的影响
- Author:
Zhuojun ZHANG
1
;
Lijuan SHEN
1
;
Hongyi LAN
2
;
Jiajing ZHAO
2
;
Liyang SHEN
2
;
Tiantian HUANG
2
;
Shuai ZHANG
2
;
Xiaodong TAN
1
;
Shu LU
1
Author Information
1. Wuxi Hospital Affiliated to Nanjing University of Chinese Medicine，Wuxi 214071，China
2. Nanjing University of Chinese Medicine，Nanjing 210023，China
- Publication Type:Journal Article
- Keywords:
Shenqi Yangxin decoction;
ischemic cardiomyopathy;
left ventricular ejection fraction;
H2S;
Ca2+
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(11):210-217
- CountryChina
- Language:Chinese
-
Abstract:
ObjectiveTo evaluate the clinical efficacy of Shenqi Yangxin decoction in the treatment of ischemic cardiomyopathy （ICM） with Qi and Yin deficiency and blood stasis syndrome and its effect on serum hydrogen sulfide （H2S） and calcium ion （Ca2+）. MethodsA total of 64 ICM patients with Qi and Yin deficiency and blood stasis syndrome who met the inclusion criteria were randomly divided into a control group （n=32） and a treatment group （n=32）. All patients received conventional Western medicine treatment. The treatment group was additionally given Shenqi Yangxin decoction. The TCM syndrome score， Minnesota Living with Heart Failure Questionnaire （MLHFQ） score， left ventricular ejection fraction （LVEF）， N-terminal pro-B-type natriuretic peptide （NT-proBNP）， 6-minute walk test （6MWT）， New York Heart Association （NYHA） cardiac function classification， and serum H2S and Ca2+ levels were compared between the two groups pre- and post-treatment. ResultsTwo cases dropped out from each group during the study. Finally， 30 patients in each group were included in the analysis. There were no significant differences in age， gender， course of coronary heart disease， underlying diseases， and laboratory tests between the two groups. Compared with baseline， the TCM syndrome score， MLHFQ score， and NT-proBNP in both treatment group and control group decreased significantly （P<0.01）， LVEF， 6MWT， and H2S increased significantly （P<0.01）， and serum Ca2+ increased （P<0.05）. Compared with the control group after treatment， the MLHFQ score and NT-proBNP in the treatment group decreased （P<0.05）， the TCM syndrome score decreased significantly （P<0.01）， LVEF， 6MWT， and serum Ca2+ increased （P<0.05）， and H2S increased significantly （P<0.01）. The improvement degree of the NYHA cardiac function classification in the treatment group was higher than that in the control group， but there was no significant difference. ConclusionShenqi Yangxin decoction is effective in treating ICM patients with Qi and Yin deficiency and blood stasis， which could significantly improve cardiac function and quality of life， and its therapeutic effect may be related to the regulation of serum H2S and Ca2+ levels.
