Research progress on the molecular genetic mechanism of Parkinson's disease.
10.3760/cma.j.cn511374-20251021-00617
- Author:
Wei QUAN
1
,
2
Author Information
1. Linyi Hospital of Traditional Chinese Medicine Affiliated to Shandong University of Traditional Chinese Medicine, Linyi, Shandong 273400, China. nongyue198567@
2. com.
- Publication Type:English Abstract
- MeSH:
Humans;
Parkinson Disease/metabolism*;
alpha-Synuclein/genetics*;
Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics*;
Genetic Predisposition to Disease;
Protein Kinases/genetics*;
Animals;
Glucosylceramidase/genetics*;
Ubiquitin-Protein Ligases/genetics*
- From:
Chinese Journal of Medical Genetics
2026;43(2):151-157
- CountryChina
- Language:Chinese
-
Abstract:
The pathogenesis of Parkinson's disease is closely related to genetic factors. This article has systematically reviewed the research progress of molecular genetic mechanism on Parkinson's disease by focusing on the role of six high-penetrance pathogenic genes (SNCA, LRRK2, PRKN, PINK1, PARK7, and VPS35) and some risk genes (such as GBA1). These genetic variants eventually converge in three core pathogenic biological pathways, including lysosomal-autophagy pathway disorder, mitochondrial quality control disorder and α-synuclein metabolic abnormality. In-depth understanding of these molecular mechanisms is of great significance for the development of targeted therapy and realization of precision medicine for this disease.
