Association of TNFRSF11B gene rs2073618 and rs3102735 polymorphisms with susceptibility to Gastric cancer.
10.3760/cma.j.cn511374-20241013-00551
- Author:
Xuan TANG
1
;
Dandan GONG
;
Shiqi ZHANG
;
Xiaoyan WANG
;
Yu FAN
Author Information
1. Cancer Institute, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212002, China. yuf36@sina.com.
- Publication Type:Journal Article
- MeSH:
Humans;
Stomach Neoplasms/genetics*;
Polymorphism, Single Nucleotide;
Male;
Female;
Genetic Predisposition to Disease;
Middle Aged;
Case-Control Studies;
Osteoprotegerin/genetics*;
Aged;
Adult;
Genotype
- From:
Chinese Journal of Medical Genetics
2025;42(5):579-586
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVE:To explore the association between single nucleotide polymorphism (SNP) rs2073618 and rs3102735 of the TNFRSF11B gene and the susceptibility to gastric cancer.
METHODS:A case-control study was conducted. A total of 577 patients with primary gastric cancer treated at Zhenjiang First People's Hospital from May 2013 to June 2017 were selected as the case group, and 678 healthy individuals who underwent physical examinations at the same hospital during the same period were enrolled as the control group. Blood samples were collected from both groups, and genomic DNA was extracted. The target gene fragments were amplified using PCR, and genotyping was performed using the Snapshot technique. Statistical analysis was conducted using SPSS v2.0 software. This study was approved by the Medical Ethics Committee of the Zhenjiang First People's Hospital (Ethics No. 20150083).
RESULTS:The smoking rate was significantly higher in the case group than in the control group (P = 0.006). The T>C polymorphism at the rs3102735 locus of the TNFRSF11B gene was significantly associated with an increased risk of gastric cancer (CC vs. TT: OR = 2.164, 95%CI = 1.063~4.406, P = 0.030). In contrast, the rs2073618 polymorphism did not show a significant association with gastric cancer susceptibility (P > 0.05). Stratified analysis by age, gender, smoking status, and drinking status revealed no significant association between the rs2073618 polymorphism and gastric cancer susceptibility (P > 0.05). However, the rs3102735 polymorphism showed a significant association with gastric cancer risk in individuals over 62 years of age (CC vs. TT: OR = 5.44, 95%CI = 1.54~19.21, P = 0.003).
CONCLUSION:The rs3102735 polymorphism of the TNFRSF11B gene may be associated with susceptibility to gastric cancer, particularly in older populations. This polymorphism could serve as a potential indicator for identifying high-risk groups for gastric cancer.
