Research advances on the genetic pathogenesis and gene therapy for pancreatitis.
10.3760/cma.j.cn511374-20240814-00442
- Author:
Yizhou ZHENG
1
;
Yuanchen WANG
;
Wenbin ZOU
Author Information
1. Research Institute for Pancreatic Diseases of Shanghai, Department of Gastroenterology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. dr.wenbinzou@hotmail.com.
- Publication Type:English Abstract
- MeSH:
Humans;
Genetic Therapy/methods*;
Pancreatitis/etiology*;
Genetic Predisposition to Disease;
Animals
- From:
Chinese Journal of Medical Genetics
2025;42(1):122-127
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatitis is an inflammatory disease influenced by both environmental and genetic factors. It has a high prevalence and mortality rate worldwide, with no radical cure. Breakthroughs have been recently made in genetic research of pancreatitis. Susceptibility genes and pathways have been continuously discovered, which highlighted the roles of genetic factors in hypertriglyceridemic and chronic pancreatitis. Gene therapy may offer radical cure for pancreatitis, though it has remained at the research phase. This article has reviewed the genetic pathogenesis of pancreatitis and current status of gene therapy research, with an aim to provide a reference for attaining definitive cure for the disease.
