Research Advances and Challenges of miR-223 in Cardiovascular Disease

VernacularTitle:miR-223在心血管疾病中的研究进展与挑战
Author: Liqin HU ¹ ; Ruifang LIU ; Wentong MA ; Guowei WANG
Author Information

1. 新疆医科大学研究生院,乌鲁木齐 830054;新疆军区总医院老年医学科,乌鲁木齐 830000
Publication Type:Journal Article
Keywords: miR-223; myocardial ischemia syndrome; myocardial fibrosis; atrial fibrillation; therapeutic target
From: Medical Journal of Peking Union Medical College Hospital 2025;16(5):1260-1265
CountryChina
Language:Chinese
Abstract: Cardiovascular disease(CVD)is currently one of the most severe diseases endangering human health,encompassing myocardial ischemia syndrome,myocardial fibrosis,atrial fibrillation,and other conditions.MicroRNAs(miRNAs/miR)are a class of small non-coding RNAs that can bind to specific se-quences and subsequently regulate post-transcriptional processing,translation,or epigenetic modifications,thereby modulating gene expression.Studies have found that miR-223 is associated with the occurrence and de-velopment of CVD and represents a potential specific therapeutic target.This article summarizes the relevant re-search on miR-223 in CVD,focusing on myocardial ischemia syndrome,myocardial fibrosis,and atrial fibrilla-tion,and discusses its application prospects and challenges as a specific therapeutic target,providing new ideas for the diagnosis and treatment of CVD.