Hematopoietic Engineering:The Current Status and Prospects of In Vitro Erythrocyte Production Technology
10.12290/xhyxzz.2024-0612
- VernacularTitle:血液再生工程:体外红细胞制备技术的研究现状与前景
- Author:
Qianli ZHUO
1
;
Zhaojun ZHANG
;
Xiangdong FANG
Author Information
1. 国家生物信息中心,北京 100101;中国科学院北京基因组研究所,北京 100101;中国科学院大学,北京 100049
- Publication Type:Journal Article
- Keywords:
in vitro erythrocyte production;
immortalized red blood cell lines;
enucleation;
culture
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(5):1179-1184
- CountryChina
- Language:Chinese
-
Abstract:
In vitro erythrocyte manufacturing technology offers a novel solution for transfusion therapy,en-suring sustainable blood supply,reducing dependence on donors,and minimizing the risk of infectious disease transmission.This review summarizes recent advancements in in vitro erythrocyte production,including techniques for generating red blood cells(RBC)from various cell sources,with a focus on the cultivation and development of immortalized erythroid cell lines.The importance of enhancing enucleation efficiency and ensuring the safety of immortalized erythroid cells is emphasized.Additionally,the potential and challenges in clinical translation are discussed,aiming to provide new insights for future sustainable RBC supply and therapeutic applications.
