Impact of FASN-enriched EVs on endothelial cell function in obstructive sleep apnea hypopnea syndrome
10.1016/j.jpha.2025.101251
- Author:
Yuan TIAN
1
;
Dan ZHANG
;
Huaian YANG
;
Xiaoli ZHANG
;
Shengqun XU
Author Information
1. Department of Otolaryngology Head and Neck Surgery,Shengjing Hospital of China Medical University,Shenyang 110004,China
- Publication Type:Journal Article
- Keywords:
Obstructive sleep apnea hypopnea syndrome;
Extracellular vesicles;
Fatty acid synthase;
Fatty acid metabolism;
Proteomics
- From:
Journal of Pharmaceutical Analysis
2025;15(5):1127-1144
- CountryChina
- Language:English
-
Abstract:
Endothelial dysfunction is a key factor linking obstructive sleep apnea hypopnea syndrome(OSAHS)with cardiovascular diseases.In this study,we used advanced proteomics and metabolomics approaches to investigate the impact of extracellular vesicles(EVs)derived from the serum of OSAHS patients on endothelial function.Our multi-omics analysis identified dysregulated pathways related to fatty acid metabolism,apoptosis regulation,and inflammatory responses,highlighting fatty acid synthase(FASN)as a crucial player in OSAHS-induced endothelial dysfunction.Both in vitro and in vivo experiments demonstrated that FASN-enriched EVs impair endothelial cell viability and disrupt metabolic homeo-stasis,offering new insights for the development of targeted therapies for cardiovascular complications associated with OSAHS.
