Role and mechanism of T helper 17 cells/regulatory T cells immune balance regulated by the TGF-β1/Smad signaling pathway mediated in nonalcoholic steatohepatitis
- VernacularTitle:TGF-β1/Smad信号通路调控Th17/Treg免疫平衡在非酒精性脂肪性肝炎中的机制及作用
- Author:
Qian WANG
1
;
Kaiyang LI
;
Mei YANG
;
Hang ZHANG
;
Shengjin ZHU
;
Qi ZHAO
;
Jing HUANG
Author Information
- Publication Type:Journal Article
- Keywords: Non-alcoholic Fatty Liver Disease; Transforming Growth Factor beta1; Smad Proteins; T-Lymphocytes,Helper-Inducer; T-Lymphocytes,Regulatory
- From: Journal of Clinical Hepatology 2025;42(5):942-947
- CountryChina
- Language:Chinese
- Abstract: Nonalcoholic steatohepatitis(NASH)is a chronic metabolic disease characterized by hepatocyte fatty degeneration and ballooning degeneration,and it plays an important role in the progression of hepatic steatosis.Recent studies have shown that immune homeostasis imbalance between T helper 17(Th17)and regulatory T(Treg)cells are closely associated with the pathological process of NASH.Transforming growth factor-β1(TGF-β1)is a key cytokine for regulating the differentiation and proliferation of Th17/Treg cells,and TGF-β1 binds to its receptor and activates the Smad signaling pathway,thereby regulating the immune balance of Th17/Treg cells and the expression of inflammatory factors and participating in the repair of liver inflammation.This article systematically reviews the molecular mechanism of the TGF-β1/Smad signaling pathway in affecting NASH by regulating the immune balance of Th17/Treg cells,in order to provide a theoretical basis for the research on the pathogenesis of NASH and related treatment strategies.
