Gold nanorod-based engineered nanogels for cascade-amplifying photothermo-enzymatic synergistic therapy
10.1016/j.jpha.2024.101139
- Author:
Ling DING
1
;
Xiaoshan WANG
;
Qing WU
;
Xia WANG
;
Qigang WANG
Author Information
1. School of Chemical Science and Engineering,Tongji University,Shanghai,200092,China
- Publication Type:Journal Article
- Keywords:
Nanogels;
Photothermal-enzymatic synergistic;
therapy;
ROS-Based nanodynamic therapies
- From:
Journal of Pharmaceutical Analysis
2024;14(12):1921-1931
- CountryChina
- Language:English
-
Abstract:
Reactive oxygen species(ROS)-mediated anticancer modalities,which disturb the redox balance of cancer cells through multi-pathway simulations,hold great promise for effective cancer management Among these,cooperative physical and biochemical activation strategies have attracted increasing attention because of their spatiotemporal controllability,low toxicity,and high therapeutic efficacy.Herein,we demonstrate a nanogel complex as a multilevel ROS-producing system by integrating chloroperoxidase(CPO)into gold nanorod(AuNR)-based nanogels(ANGs)for cascade-amplifying pho-tothermal-enzymatic synergistic tumor therapy.Benefiting from photothermal-induced hyperthermia upon near-infrared(NIR)laser exposure,the exogenous ROS(including H202)were boosted by the AuNR nanogel owing to the intercellular stress response.This ultimately promoted the efficient enzyme-catalyzed reaction of loaded CPO combined with the rich endogenous H2O2 in tumor cells to signifi-cantly elevate intracellular ROS levels above the threshold for improved therapeutic outcomes.Both in vitro and in vivo studies have verified the cascade-amplifying ROS-mediated antitumor effects,providing feasible multimodal synergistic tactics for tumor treatment.
