Mitochondria and myocardial ischemia/reperfusion injury:Effects of Chinese herbal medicine and the underlying mechanisms
10.1016/j.jpha.2024.101051
- Author:
Chuxin ZHANG
1
;
Xing CHANG
;
Dandan ZHAO
;
Yu HE
;
Guangtong DONG
;
Lin GAO
Author Information
1. Beijing University of Chinese Medicine,Beijing,100029,China
- Publication Type:Journal Article
- Keywords:
Myocardial ischemia-reperfusion injury;
Mitochondria;
Mitochondrial quality control;
Oxidative stress;
Traditional Chinese medicine
- From:
Journal of Pharmaceutical Analysis
2025;15(2):359-374
- CountryChina
- Language:English
-
Abstract:
Ischemic heart disease(IHD)is associated with high morbidity and mortality rates.Reperfusion therapy is the best treatment option for this condition.However,reperfusion can aggravate myocardial damage through a phenomenon known as myocardial ischemia/reperfusion(I/R)injury,which has recently gained the attention of researchers.Several studies have shown that Chinese herbal medicines and their natural monomeric components exert therapeutic effects against I/R injury.This review outlines the current knowledge on the pathological mechanisms through which mitochondria participate in I/R injury,focusing on the issues related to energy metabolism,mitochondrial quality control disorders,oxidative stress,and calcium.The mechanisms by which mitochondria mediate cell death have also been discussed.To develop a resource for the prevention and management of clinical myocardial I/R damage,we compiled the most recent research on the effects of Chinese herbal remedies and their monomer components.
