Advanced bioanalytical techniques for pharmacokinetic studies of nanocarrier drug delivery systems
10.1016/j.jpha.2024.101070
- Author:
Xiangjun MENG
1
;
Jiayi YAO
;
Jingkai GU
Author Information
1. School of Pharmaceutical Science and Technology,Faculty of Medicine,Tianjin University,Tianjin,300072,China
- Publication Type:Journal Article
- Keywords:
Nanocarrier drug delivery systems;
Bioanalysis;
Pharmacokinetics;
Sample fractionation technique
- From:
Journal of Pharmaceutical Analysis
2025;15(1):19-29
- CountryChina
- Language:English
-
Abstract:
Significant investment in nanocarrier drug delivery systems(Nano-DDSs)has yielded only a limited number of successfully marketed nanomedicines,highlighting a low rate of clinical translation.A pri-mary contributing factor is the lack of foundational understanding of in vivo processes.Comprehensive knowledge of the pharmacokinetics of Nano-DDSs is essential for developing more efficacious nano-medicines and accurately evaluating their safety and associated risks.However,the complexity of Nano-DDSs has impeded thorough and systematic pharmacokinetic studies.Key components of pharmacoki-netic investigations on Nano-DDSs include the analysis of the released drug,the encapsulated drug,and the nanomaterial,which present a higher level of complexity compared to traditional small-molecule drugs.Establishing an appropriate approach for monitoring the pharmacokinetics of Nano-DDSs is crucial for facilitating the clinical translation of nanomedicines.This review provides an overview of advanced bioanalytical methodologies employed in studying the pharmacokinetics of anticancer organic Nano-DDSs over the past five years.We hope that this review will enhance the understanding of the pharmacokinetics of Nano-DDSs and support the advancement of nanomedicines.
