Atypical Hemolytic Uremic Syndrome with Eosinophilia and Purtscher-like Retinopathy;A Case Report
10.12290/xhyxzz.2024-0471
- VernacularTitle:合并嗜酸性粒细胞增多,出现Purtscher样视网膜病变的非典型溶血性尿毒症一例
- Author:
Qimin MEI
1
;
Jiayuan DAI
;
Yecheng LIU
;
Min SHEN
;
Huadong ZHU
Author Information
1. 中国医学科学院北京协和医院急诊科,北京 100730;中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室,北京 100730
- Publication Type:Journal Article
- Keywords:
atypical hemolytic uremic syndrome;
eosinophilia;
renal insufficiency;
vision loss
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(1):256-262
- CountryChina
- Language:Chinese
-
Abstract:
Atypical hemolytic uremic syndrome(aHUS),a rare disease caused by complement abnor-malities,is characterized by microangiopathic hemolytic anemia,thrombocytopenia,and acute kidney injury.In this paper,we report a patient with severe renal insufficiency with rapidly progressive decline in binocular visual acuity,who developed eosinophilia during the course of the disease,and was diagnosed with aHUS after excluding other diseases.After glucocorticoid treatment,eosinophils decreased to normal,and after treatment with plasmapheresis combined with eculizumab,renal function tended to be stable,platelets returned to normal,but visual acuity did not improve significantly.This article reviews the diagnosis and treatment process of this patient and incorporates the review of literature,in the hope of providing reference for clinicians.
