Current Status of Diagnosis and Treatment of High-risk Resistant and Recurrent Gestational Trophoblastic Neoplasia

VernacularTitle:高危耐药及复发妊娠滋养细胞肿瘤诊疗现状
Author: Mingyi MAO ¹ ; Fang JIANG ; Yang XIANG
Author Information

1. 中国医学科学院北京协和医院妇产科国家妇产疾病临床研究中心,北京 100730;中国医学科学院北京协和医学院临床医学专业试点班,北京 100730
Publication Type:Journal Article
Keywords: gestational trophoblastic neoplasia; high-risk; resistance; recurrence
From: Medical Journal of Peking Union Medical College Hospital 2025;16(1):157-162
CountryChina
Language:Chinese
Abstract: Gestational trophoblastic neoplasia(GTN)patients can be classified into low-risk and high-risk patients based on the International Federation of Gynecology and Obstetrics(FIGO)staging and scoring system.High-risk patients have a higher risk of resistance to single-agent chemotherapy and require combination chemotherapy.Even worse,there are some high-risk patients who develop resistance to combination chemother-apy or experience recurrence after cure.These patients exhibit strong heterogeneity and pose significant challen-ges to subsequent treatment,thus attracting considerable attention in recent years.Therefore,this article aims to review the risk factors and treatment strategies for high-risk resistant and recurrent GTN patients,in order to provide a basis for early identification of high-risk patients and their precise treatment.