Progress in the Study of Polymyxin Heteroresistance Molecular Mechanisms
10.12290/xhyxzz.2024-0159
- VernacularTitle:多黏菌素异质性耐药机制研究进展
- Author:
Yanbing LI
1
;
Menglan ZHOU
;
Yingchun XU
Author Information
1. 中国医学科学院北京协和医院检验科,北京 100730;中国医学科学院北京协和医院疑难重症及罕见病国家重点实验室,北京 100730;中国医学科学院北京协和医学院研究生院,北京 100730;中国医学科学院北京协和医院侵袭性真菌病机制研究与精准诊断北京市重点实验室,北京 100730
- Publication Type:Journal Article
- Keywords:
polymyxins;
heteroresistance;
gram-negative bacteria;
molecular mechanism
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(1):177-183
- CountryChina
- Language:Chinese
-
Abstract:
Polymyxins,a class of cyclic peptide antibiotics,have become the last line of defense against gram-negative bacterial infections as the number of multidrug-resistant bacteria continues to rise.Het-eroresistance refers to the presence of subpopulations within the same strain with varying sensitivities to antibi-otics,which cannot be detected by standard clinical tests and may result in treatment failure.In several com-mon gram-negative bacteria,mutations in the PhoPQ and PmrAB two-component systems are key contributors to polymyxin heteroresistance.This review aims to summarize recent research on the mechanisms of polymyxin heteroresistance in gram-negative bacteria,so as to provide insights for developing rapid detection methods and improving clinical treatment strategies.
