Progress in Clinical Diagnosis and Management of Short Stature in Ehlers-Danlos Syndromes
10.12290/xhyxzz.2024-0173
- VernacularTitle:Ehlers-Danlos综合征中身材矮小的诊疗进展
- Author:
Kexin XU
1
;
Guozhuang LI
;
Zhihong WU
;
Jianguo ZHANG
;
Nan WU
Author Information
1. 中国医学科学院北京协和医院骨科,北京 100730;中国医学科学院北京协和医院骨骼医疗大数据创新应用北京市重点实验室,北京 100730;中国医学科学院北京协和医院中国医学科学院脊柱畸形大数据研究与应用重点实验室,北京 100730
- Collective Name:DISCO(Deciphering Disorders Involving Scoliosis & Comorbidities)Study Group
- Publication Type:Journal Article
- Keywords:
Ehlers-Danlos syndromes;
short stature;
multi-disciplinary treatment;
deep phenotyping;
rare disease
- From:
Medical Journal of Peking Union Medical College Hospital
2025;16(1):163-170
- CountryChina
- Language:Chinese
-
Abstract:
Ehlers-Danlos syndromes(EDS)are a group of rare hereditary connective tissue disorders characterized by joint hypermobility,skin hyperextensibility,and tissue fragility.Short stature is defined as a height that is two standard deviations or more below the average height for individuals of the same age,sex,and race.The etiopathogenesis of short stature is complicated.Early detection and appropriate intervention are essential in disease treatment.However,short stature is not common among all EDS subtypes.It is frequently observed in patients with rare subtypes,such as spondylodysplastic EDS,dermatosparaxis EDS,and musculo-contractural EDS.Besides,height may be affected by other factors including spinal curvature and malnutrition.Deep phenotyping and multidisciplinary team approaches are recommended for the diagnosis and management.Short stature in patients with EDS has not been sufficiently acknowledged in China.There is currently a lack of high-level evidence for the treatment of EDS-related short stature.Therefore,this review aims to present recent progress of diagnosis and management of short stature in patients with EDS.Further studies focusing on short stature in rare subtypes are necessary to advance precision medicine and enhance patient care.
