Tailoring a traditional Chinese medicine prescription for complex diseases:A novel multi-targets-directed gradient weighting strategy
10.1016/j.jpha.2025.101199
- Author:
Zhe YU
1
;
Teng LI
;
Zhi ZHENG
;
Xiya YANG
;
Xin GUO
;
Xindi ZHANG
;
Haoying JIANG
;
Lin ZHU
;
Bo YANG
;
Yang WANG
;
Jiekun LUO
;
Xueping YANG
;
Tao TANG
;
En HU
Author Information
1. Institute of Integrative Medicine,Department of Integrated Traditional Chinese and Western Medicine,Xiangya Hospital,Central South University,Changsha,410008,China
- Publication Type:Journal Article
- Keywords:
Traditional Chinese medicine;
Prescription formulation;
Gradient weighting strategy;
Multiple targets;
Intracerebral hemorrhage
- From:
Journal of Pharmaceutical Analysis
2025;15(4):804-816
- CountryChina
- Language:English
-
Abstract:
Traditional Chinese medicine(TCM)exerts integrative effects on complex diseases owing to the char-acteristics of multiple components with multiple targets.However,the syndrome-based system of diagnosis and treatment in TCM can easily lead to bias because of varying medication preferences among physicians,which has been a major challenge in the global acceptance and application of TCM.Therefore,a standardized TCM prescription system needs to be explored to promote its clinical application.In this study,we first developed a gradient weighted disease-target-herbal ingredient-herb network to aid TCM formulation.We tested its efficacy against intracerebral hemorrhage(ICH).First,the top 100 ICH targets in the GeneCards database were screened according to their relevance scores.Then,SymMap and Traditional Chinese Medicine Systems Pharmacology(TCMSP)databases were applied to find out the target-related ingredients and ingredient-containing herbs,respectively.The relevance of the resulting ingredients and herbs to ICH was determined by adding the relevance scores of the corresponding targets.The top five ICH therapeutic herbs were combined to form a tailored TCM prescriptions.The absorbed components in the serum were detected.In a mouse model of ICH,the new prescription exerted multifaceted effects,including improved neurological function,as well as attenuated neuronal damage,cell apoptosis,vascular leakage,and neuroinflammation.These effects matched well with the core pathological changes in ICH.The multi-targets-directed gradient-weighting strategy presents a promising avenue for tailoring precise,multipronged,unbiased,and standardized TCM prescriptions for complex diseases.This study provides a paradigm for advanced achievements-driven modern innovation in TCM concepts.
