Mitochondrial quality control disorder in neurodegenerative disorders:Potential and advantages of traditional Chinese medicines
10.1016/j.jpha.2024.101146
- Author:
Lei XU
1
;
Tao ZHANG
;
Baojie ZHU
;
Honglin TAO
;
Yue LIU
;
Xianfeng LIU
;
Yi ZHANG
;
Xianli MENG
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources,Innovative Institute of Chinese Medicine and Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China;College of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China
- Publication Type:Journal Article
- Keywords:
Mitochondrial quality control;
Neurodegenerative disorder;
Traditional Chinese medicine
- From:
Journal of Pharmaceutical Analysis
2025;15(4):742-758
- CountryChina
- Language:English
-
Abstract:
Neurodegenerative disorders(NDDs)are prevalent chronic conditions characterized by progressive synaptic loss and pathological protein alterations.Increasing evidence suggested that mitochondrial quality control(MQC)serves as the key cellular process responsible for clearing misfolded proteins and impaired mitochondria.Herein,we provided a comprehensive analysis of the mechanisms through which MQC mediates the onset and progression of NDDs,emphasizing mitochondrial dynamic stability,the clearance of damaged mitochondria,and the generation of new mitochondria.In addition,traditional Chinese medicines(TCMs)and their active monomers targeting MQC in NDD treatment have been demonstrated.Consequently,we compiled the TCMs that show great potential in the treatment of NDDs by targeting MQC,aiming to offer novel insights and a scientific foundation for the use of MQC stabilizers in NDD prevention and treatment.
