The role of mitochondria transfer in cancer biological behavior,the immune system and therapeutic resistance
10.1016/j.jpha.2024.101141
- Author:
Xintong LYU
1
;
Yangyang YU
;
Yuanjun JIANG
;
Zhiyuan LI
;
Qiao QIAO
Author Information
1. Department of Radiation Oncology,First Hospital of China Medical University,Shenyang,110001,China
- Publication Type:Journal Article
- Keywords:
Mitochondria transfer;
Cancer biological behavior;
Immune system;
Therapeutic resistance
- From:
Journal of Pharmaceutical Analysis
2025;15(3):511-522
- CountryChina
- Language:English
-
Abstract:
Mitochondria play a crucial role as organelles,managing several physiological processes such as redox balance,cell metabolism,and energy synthesis.Initially,the assumption was that mitochondria primarily resided in the host cells and could exclusively transmit from oocytes to offspring by a mechanism known as vertical inheritance of mitochondria.Recent scholarly works,however,suggest that certain cell types transmit their mitochondria to other developmental cell types via a mechanism referred to as inter-cellular or horizontal mitochondrial transfer.This review details the process of which mitochondria are transferred across cells and explains the impact of mitochondrial transfer between cells on the efficacy and functionality of cancer cells in various cancer forms.Specifically,we review the role of mitochondria transfer in regulating cellular metabolism restoration,excess reactive oxygen species(ROS)generation,proliferation,invasion,metastasis,mitophagy activation,mitochondrial DNA(mtDNA)inheritance,im-mune system modulation and therapeutic resistance in cancer.Additionally,we highlight the possibility of using intercellular mitochondria transfer as a therapeutic approach to treat cancer and enhance the efficacy of cancer treatments.
