Advanced treatment strategies for high-altitude pulmonary hypertension employing natural medicines:A review
10.1016/j.jpha.2024.101129
- Author:
Zahra BATOOL
1
;
Amjad-Kamal MOHAMMAD
;
Bairong SHEN
Author Information
1. Center of High Altitude Medicine,West China Hospital,Sichuan University,Chengdu,610041,China
- Publication Type:Journal Article
- Keywords:
High-altitude illness;
High-altitude pulmonary hypertension;
Chinese medicine;
Natural remedies;
Hypoxia;
Pulmonary artery pressure
- From:
Journal of Pharmaceutical Analysis
2025;15(3):534-546
- CountryChina
- Language:English
-
Abstract:
High-altitude pulmonary hypertension(HAPH)occurs when blood pressure in the pulmonary arteries rises due to exposure to high altitudes above 2,500 m.At these elevations,reduced atmospheric pressure leads to lower oxygen levels,triggering a series of physiological responses,including pulmonary artery constriction,which elevates blood pressure.This review explored the complex pathophysiological mechanisms of HAPH and reviewed current pharmaceutical interventions for its management.Mean-while,this review particularly emphasized on the emerging research concerning Chinese medicinal plants as potential treatments for HAPH.Traditional Chinese medicines are rich in diverse natural in-gredients that show significant promise in alleviating HAPH symptoms.We reviewed both in vitro and in vivo studies to assess the efficacy,safety,and mechanisms of these natural medicines,along with their potential adverse effects.Additionally,this review highlighted new alternative natural remedies,underscoring the need for ongoing research to expand available treatment options for HAPH.
