Unlocking the dual role of autophagy:A new strategy for treating lung cancer
10.1016/j.jpha.2024.101098
- Author:
Fei TANG
1
;
Jing-Nan ZHANG
;
Xiao-Lan ZHAO
;
Li-Yue XU
;
Hui AO
;
Cheng PENG
Author Information
1. State Key Laboratory of Southwestern Chinese Medicine Resources,Chengdu University of Traditional Chinese Medicine,Chengdu,611137,China
- Publication Type:Journal Article
- Keywords:
Lung cancer;
Cell death;
Autophagy;
Natural products;
Small molecules
- From:
Journal of Pharmaceutical Analysis
2025;15(3):523-533
- CountryChina
- Language:English
-
Abstract:
Lung cancer exhibits the highest incidence and mortality rates among cancers globally,with a five-year overall survival rate alarmingly below 20％.Targeting autophagy,though a controversial therapeutic strategy,is extensively employed in clinical practice.Current research is actively pursuing various therapeutic strategies using small molecules to exploit the dual function of autophagy.Nevertheless,the pivotal question of enhancing or inhibiting autophagy in cancer therapy merits further attention.This review aims to provide a comprehensive overview of the mechanisms of autophagy in lung cancer.It also explores recent advances in targeting cytotoxic autophagy and inhibiting protective autophagy with small molecules to induce cell death in lung cancer cells.Notably,most autophagy-targeting drugs,primarily natural small molecules,have demonstrated that activating cytotoxic autophagy effectively induces cell death in lung cancer,as opposed to inhibiting protective autophagy.These insights contribute to identifying druggable targets and drug candidates for potential autophagy-related lung cancer therapies,offering promising approaches to combat this disease.
