Potential of natural drug modulation of endoplasmic reticulum stress in the treatment of myocardial injury
10.1016/j.jpha.2024.101034
- Author:
Kai YANG
1
;
Ping ZHANG
;
Jixin LI
;
Genming ZHANG
;
Xing CHANG
Author Information
1. Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing,100053,China;Shandong University of Traditional Chinese Medicine,Jinan,250355,China
- Publication Type:Journal Article
- Keywords:
Natural products;
Endoplasmic reticulum stress;
Myocardial injury;
Unfolded protein response;
Cardiovascular disease
- From:
Journal of Pharmaceutical Analysis
2024;14(11):1567-1587
- CountryChina
- Language:English
-
Abstract:
Myocardial injury(MI)is a common occurrence in clinical practice caused by various factors such as ischemia,hypoxia,infection,metabolic abnormalities,and inflammation.Such damages are character-ized by a reduction in myocardial function and cardiomyocyte death that can result in dangerous out-comes such as cardiac failure and arrhythmias.An endoplasmic reticulum stress(ERS)-induced unfolded protein response(UPR)is triggered by several stressors,and its intricate signaling networks are instrumental in both cell survival and death.Cardiac damage frequently triggers ERS in response to different types of injuries and stress.High levels of ERS can exacerbate myocardial damage by inducing necrosis and apoptosis.To target ERS in MI prevention and treatment,current medical research is focused on identifying effective therapy approaches.Traditional Chinese medicine(TCM)is frequently used because of its vast range of applications and low risk of adverse effects.Various studies have demonstrated that active components of Chinese medicines,including polyphenols,saponins,and al-kaloids,can reduce myocardial cell death,inflammation,and modify the ERS pathway,thus preventing and mitigating cardiac injury.Thus,this paper aims to provide a new direction and scientific basis for targeting ERS in MI prevention and treatment.We specifically summarize recent research progress on the regulation mechanism of ERS in MI by active ingredients of TCM.
