Helicobacter pylori infection in physical examination population and its correlations with hypertension,glucose and lipid metabolism
- VernacularTitle:体检人群幽门螺杆菌感染情况及其与高血压、糖脂代谢的相关性
- Author:
Yan GAO
1
;
Dan ZHANG
1
;
Qian LI
1
;
Junbo ZHANG
1
;
Liu LIU
1
;
Ya'nan ZHU
1
;
Shanshan GUO
1
Author Information
- Publication Type:Journal Article
- Keywords: physical examination population; Helicobacter pylori infection; hypertension; glycolipid metabolism; total cholesterol
- From: Journal of Clinical Medicine in Practice 2024;28(23):100-104
- CountryChina
- Language:Chinese
- Abstract: Objective To investigate the infection of Helicobacter pylori(Hp)and its relation-ships with hypertension,glucose and lipid metabolism in the physical examination population.Meth-ods A total of 287 individuals undergoing physical examinations were selected as study subjects.Based on the results of 14C-urea breath test screening for Hp infection,participants were divided into Hp-positive group(n=125)and Hp-negative group(n=162).Baseline characteristics and glyco-lipid metabolism levels were compared between the two groups.Multivariate Logistic regression analy-sis was used to identify factors influencing Hp infection in the study population.Results The Hp in-fection rate among the 287 individuals was 43.55％.The frequency of eating out in the Hp-positive group was 34.40％,which was significantly higher than 13.58％in the Hp-negative group(P＜0.05).Fasting blood glucose(FBG),insulin resistance index(HOMA-IR),total cholesterol(TC)and triacylglycerol(TG)in the HP-positive group were significantly higher,and high-density lipopro-tein cholesterol(HDL-C)was significantly lower than that in the Hp-negative group(P＜0.05).Mult-ivariate Logistic regression analysis revealed that eating out(OR=1.401,95％CI,1.142 to 1.717),FBG(OR=3.865,95％CI,1.810 to 8.253),TC(OR=4.141,95％CI,2.025 to 8.469),TG(OR=4.259,95％CI,2.128 to 8.524)and HDL-C(OR=4.125,95％CI,1.989 to 8.552)were factors influencing Hp infection in the study population(P＜0.05).HOMA-IR was not associated with Hp infection in the study population(P＞0.05).Conclusion The prevalence of Hp infection is high among individuals undergoing physical examinations,and Hp infection has significant association with abnormalities in glycolipid metabolism,but no association with hypertension.
