Effects of biomaterials on the inflammatory response in tissue-engineered cartilage
10.3760/cma.j.cn114453-20230928-00065
- VernacularTitle:组织工程软骨中生物材料对炎症反应的影响
- Author:
Yanlong YANG
1
;
Haiyue JIANG
1
Author Information
1. 中国医学科学院北京协和医学院整形外科医院外耳整形再造中心，北京 100144
- Publication Type:Journal Article
- Keywords:
Tissue engineering;
Cartilage;
Inflammation;
Biomaterials
- From:
Chinese Journal of Plastic Surgery
2025;41(3):301-306
- CountryChina
- Language:Chinese
-
Abstract:
Cartilage tissue engineering offers a novel therapeutic approach for auricular, tracheal, and joint reconstruction. Nevertheless, once implanted into the body, tissue-engineered cartilage is confronted with host immune rejection and inflammatory responses. These responses can result in cartilage deformation and fibrosis, thereby affecting the long-term maintenance of its morphology and function. Effectively modulating immune and inflammatory responses is crucial for advancing the clinical application of engineered cartilage. This article reviewed relevant literature to analyze the mechanisms of inflammatory responses occurring after the implantation of tissue-engineered cartilage, and summarized the types and surface characteristics of biomaterials, providing a reference for the design of biomaterials in cartilage tissue engineering.
