Research progress of adipose-derived stem cells in the treatment of diabetic foot ulcers

VernacularTitle:脂肪来源干细胞治疗糖尿病足溃疡的研究进展
Author: Nating XU ¹ ; Xuejun NI ¹ ; Biao WANG ¹
Author Information

1. 福建医科大学附属第一医院整形外科，福州　350005
Publication Type:Journal Article
Keywords: Diabetes complications; Foot ulcer; Adipose tissue; Stem cells; Wound healing
From: Chinese Journal of Plastic Surgery 2025;41(7):766-771
CountryChina
Language:Chinese
Abstract: Diabetic foot ulcers (DFUs) are a common and serious complication of diabetes. Current treatment methods typically focus on controlling blood glucose levels, routine care, anti-infection, debridement, and other aspects. However, these approaches have not consistently yielded satisfactory results. Adipose-derived stem cells (ADSCs) are characterized by their diverse sources, ease of acquisition, and low immunogenicity, making them a prominent topic of research area in the field of stem cells. ADSCs have emerged as a new strategy for the treatment of DFUs. This review aims to describe the pathophysiological characteristics of diabetic foot ulcers, the advantages and biological functions of ADSCs, and their mechanisms for promoting wound healing in DFUs, thereby providing a theoretical basis for the clinical application of ADSCs in the treatment of DFUs.