Research progress on the mechanism of traditional Chinese medicine regulating oxidative stress to promote diabetic wound healing
- VernacularTitle:中药调控氧化应激促进糖尿病创面愈合的机制研究进展
- Author:
Chang LU
1
;
Ying DANG
2
;
Lu WANG
3
;
Jianping SHI
1
Author Information
1. College of Traditional Chinese Medicine，Inner Mongolia Medical University，Hohhot 010010，China
2. Medical Simulation Center，Inner Mongolia Medical University，Hohhot 010010，China
3. Laboratory and Experimental Equipment Management Center，Inner Mongolia Medical University，Hohhot 010010，China
- Publication Type:Journal Article
- Keywords:
diabetic wound;
oxidative stress;
traditional Chinese medicine;
mechanism of action
- From:
China Pharmacy
2026;37(8):1080-1084
- CountryChina
- Language:Chinese
-
Abstract:
The process of diabetic wound healing is highly complex， and the persistence of non-healing wounds is closely associated with sustained oxidative stress in the body . Traditional Chinese medicine （TCM） demonstrates unique therapeutic advantages in promoting diabetic wound repair by modulating oxidative stress through multiple targets and pathways. This article presents a systematic review of the mechanism of TCM regulating oxidative stress to promote diabetic wound healing. It has been found that TCM monomers （such as rutin， baicalin， lonicerin， and curcumin）， extracts （including aqueous extract of Gynura divaricata ， extract of Polygonatum kingianum ， extract of Ginkgo biloba leaves， etc）， and compound formulations （such as Badu shengji powder， Danggui sini decoction， Compound ANBP， etc） can effectively alleviate oxidative stress-induced damage in diabetic wounds by modulating related signaling pathways， including nuclear factor-erythroid 2-related factor 2， nuclear factor κB，advanced glycation end products （AGEs）/receptors of AGEs， and silencing information regulatory factor 1. The underlying mechanisms are mainly manifested as： activating the antioxidant defense system， inhibiting inflammatory response， and improving mitochondrial function， thereby synergistically promoting wound healing.
