Research progress on clinical applications of adenovirus vector vaccines
10.13200/j.cnki.cjb.004682
- VernacularTitle:腺病毒载体疫苗临床应用的研究进展
- Author:
Dan ZHU
1
Author Information
1. Department of Respiratory Medicine, Children’s Hospital of Chongqing Medical University, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Child Rare Diseases in Infection and Immunity, Chongqing 400014, China
- Publication Type:Journal Article
- Keywords:
Adenovirus vector vaccine;
Clinical application;
Immune response mechanism
- From:
Chinese Journal of Biologicals
2026;39(04):500-505+512
- CountryChina
- Language:Chinese
-
Abstract:
Adenovirus(Ad) vector vaccines use the modified Ad as a delivery tool to deliver the gene encoding the target antigen to the host cell, inducing humoral and cellular immune response, which have good characteristics such as stable expression of heterologous genes, strong immunogenicity and low pathogenicity, and can be produced on a large scale. The SARS-CoV-2 vaccine prepared by this platform not only curbs the spread of the epidemic in a short period of time, but also provides a technical platform and valuable experience for dealing with emerging infectious diseases in the future. It has shown significant potential in the prevention and control of infectious diseases and has become an important direction of current vaccine research. In this paper, the latest clinical application progress of Ad vector vaccines, the key challenges in the process of clinical transformation and the molecular mechanism of inducing host immune response are reviewed, in order to provide reference for related research.
