Research progress on protective efficacy of Japanese encephalitis vaccine against Japanese encephalitis GⅤ virus
- VernacularTitle:乙型脑炎疫苗对GⅤ型乙型脑炎病毒保护效果的研究进展
- Author:
Shuai SHANG
1
Author Information
- Publication Type:Journal Article
- Keywords: Japanese encephalitis virus(JEV); Japanese encephalitis live attenuated vaccine; Japanese encephalitis inactivated vaccine; Genotype; Neutralizing antibody; Protective efficacy
- From: Chinese Journal of Biologicals 2026;39(04):494-499
- CountryChina
- Language:Chinese
- Abstract: Japanese encephalitis virus(JEV) is an important zoonotic pathogen transmitted by mosquitoes. Its serotype is unique, however, based on the phylogenetic analysis of viral nucleotide sequences, it can be divided into five genotypes:genotypeⅠ(GⅠ)-GⅤ. In recent years, the GⅤ type JEV has reappeared and shown a widespread epidemic trend in many Asian countries, posing a serious challenge to the current global dominant use of G Ⅲ strain-based Japanese encephalitis vaccines. This article provides a systematic review of the research progress on the neutralizing antibody activity and in vitro and in vivo protective effects of GⅢ type Japanese encephalitis vaccine against GⅤ type JEV, providing reference for the development direction and optimization of prevention and control strategies for new Japanese encephalitis vaccines.
