Traditional Chinese Medicine Regulation of Wnt/β-catenin Signaling Pathway for Post-stroke Cognitive Impairment Treatment： A Review
10.13422/j.cnki.syfjx.20251792
- VernacularTitle:中药调控Wnt/β-catenin信号通路治疗卒中后认知障碍的研究进展
- Author:
Wanyue XU
1
;
Yanjie LI
2
;
Haoyuan LIU
2
;
Bohua WAN
2
Author Information
1. School of Rehabilitation Sciences，Henan University of Chinese Medicine，Zhengzhou 450046，China
2. Henan Provincial Hospital of Traditional Chinese Medicine，The Second Affiliated Hospital， Henan University of Chinese Medicine，Zhengzhou 450002，China
- Publication Type:Journal Article
- Keywords:
post-stroke cognitive impairment;
Wnt/β-catenin signaling pathway;
traditional Chinese medicine;
research progress
- From:
Chinese Journal of Experimental Traditional Medical Formulae
2026;32(10):337-345
- CountryChina
- Language:Chinese
-
Abstract:
Post-stroke cognitive impairment （PSCI） is a common and severe complication in stroke patients， significantly affecting their quality of life and social function. Despite increasing research on PSCI in recent years， effective therapeutic methods remain limited. The Wnt/β-catenin signaling pathway has emerged as a critical research focus in neuroscience due to its essential role in neuroprotection， neurorepair， and cognitive recovery. Dysregulation of the Wnt/β-catenin pathway is considered one of the key mechanisms in the onset and progression of PSCI. Traditional Chinese medicine （TCM）， with its multi-component， multi-target， and synergistic properties， has shown unique advantages in modulating the Wnt/β-catenin signaling pathway， providing a potential novel approach for PSCI treatment. TCM regulates the Wnt/β-catenin pathway through various mechanisms and exerts effects such as inhibiting cell apoptosis， maintaining blood-brain barrier integrity， reducing neuroinflammation， promoting neuroplasticity， and enhancing neurorepair， thereby improving post-stroke cognitive function. This review summarized the latest research progress on the regulation of the Wnt/β-catenin signaling pathway by TCM in intervening PSCI. It analyzed the mechanisms of action of various TCM components and compound formulas within this pathway， aiming to provide a theoretical basis for innovative strategies for PSCI treatment in the future and offer new research insights and practical guidance for the application of TCM in cerebrovascular diseases.
